The best interactions with the receptor are the structure model trans with the lowest interaction energy interaction. The ONIOM calculation showed the bond between the complexes of chromium(III) nicotinic with PTP is hydrogen bonding. The similar things at modelof N-coordinated to Cr with trans position interact with amino acids Leu13, Ser47, Trp49, Asn50 and Tyr131 the interaction energy is -6.5 kcal/mol. As for the structure model cis have -6.1 kcal/mol interaction energy and the amino acid Ile16, Trp49, Asn50, Arg53, Asp56 and Tyr131. The docking results showed that trans position interact with Leu13, Gly14, Cys17, Arg18, Trp49 and Asn50 with the interaction energy is -6.5 kcal/mol. The optimization of the complex structure of chromium(III) nicotinic using Gaussian 09, the docking process is performed using Autodock Vina. Chromium nicotinate has a reported acute oral LD50 of 5000 mg/kg in mice and has no effect in the Ames mutagenic assays or in gene mutation tests in mice (42). It appears in products that are referred to as a medical food used for nutritional support for conditions associated with diabetes mellitus type 2. The chromium(III) nicotinic complexes an antidiabetic supplement that have been demonstrated in vitro, to determine the role of chromium(III) nicotinic as a supplement antidiabetic learned through the docking mechanism. Chromium (III) nicotinate is an ionic substance used for chromium supplementation in some nutritional products, where it is also referred to as chromium polynicotinate. This study aims to understand the interaction between Chromium(III) nicotinate and with the position of trans and cis as a substrate with receptors Protein Tyrosine Phosphatase(PTP). The results demonstrate by comparison that Cr–N bond breaking is a much slower process than Cr–O bond fission.read more read lessĪbstract: Docking simulation is important in the process of drug design, mainly used for the prediction of interactions receptor(protein)–substrate. The Cr–N bond breaking proceeds via two paths: spontaneous and acid-catalyzed kobs=k0 + kHQH, where k0 and kH are the spontaneous and acid catalyzed rate constants and QH is the protonation constant of the carboxylic group in the N-bonded nicotinic acid. The rate of Cr–O bond breaking is dependent: kobs=kHQH, where kH is the acid-catalyzed rate constant and QH is the protonation constant of the nonbonded oxygen atom in the O-coordinated ligand. The rate equations were determined and a mechanism is proposed. The kinetics of nicotinate ligand liberation were studied spectrophotometrically in the 0.1–1.0 m HClO4 range, at I=1.0 m. Keep out of reach of children.Abstract: Two new chromium(III)–nicotinate complexes, cis-− and cis-−, were obtained and characterized in solution (where O-nic=O-bonded and N-nic=N-bonded nicotinic acid). No binders.Ĭaution: As with any natural health product, you should consult a healthcare practitioner prior to use of this product, especially if you are pregnant or breastfeeding. Non-Medicinal Ingredients: Vegetable-grade magnesium stearate, vegetable capsule, microcrystalline cellulose. Be sure to have chromium by your side when those sweet cravings hitĭirections: Adults - Take one (1) - two (2) capsule per day or as directed by a healthcare practitioner.Ĭhromium (TRAACS® Chromium Nicotinate Glycinate Chelate) 200 mcg.Superior formulation when it comes to absorption and gentleness.A blend of chromium, glycine and niacin (vitamin B3).Be sure to have chromium by your side when those sweet cravings hit. This particular composition is considered to be one of the safest and most efficient delivery forms of chromium. Chromium Nicotinate Glycinate 200 provides support for healthy glucose metabolism.ĬanPrev’s Chromium Nicotinate Glycinate 200 contains a blend of chromium, glycine and niacin (vitamin B3) and is a superior formulation when it comes to absorption and gentleness.
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